Angelika Dannert
Neuroscience PostDoc
LMU Munich, Institute for Stroke and Dementia Research
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I'm a postdoctoral researcher in the lab of Prof. Dominik Paquet at the Institute for Stroke and Dementia Research (ISD) at LMU Munich. My research focuses on developing new ways to model dementia using induced pluripotrent stem cells and gene editing tools.
I completed my PhD in Systemic Neurosciences in 2024 at the Graduate School of Systemic Neurosciences (LMU Munich). I've always been drawn to science, and early on I knew I wanted to understand the molecular and cellular basis of disease. Therefore, I studied Molecular Medicine, earning a B.Sc. from the University of Tübingen and an M.Sc. from the University of Göttingen in Germany.
During my studies, I gained profound research experience across Europe and the US - at the Vrije Universiteit Amsterdam, the University of Zürich, Stanford University, and VIB Leuven. I also spent some time working in a biotech start-up in Heidelberg, which gave me a glimpse into the industry side of science.
Research interests
Research interests
Induced pluripotent stem cell-based modeling of human disease and their use for regenerative medicine
Gene editing for disease modelling and therapeutic approaches
Molecular and cellular mechanisms underlying neurodegenerative and neurodevelopmental disorders
Deciphering cell-autonomous and non-cell-autonomous effects
Using rare disease variants to investigate common disease mechanisms
Publications
Publications
Schellinger IN, Dannert A, Hoffmann A, Chodisetti G, Mattern K, Petzold A, Klöting N, Schuster A, Wagenhäuser MU, Emrich F, Stumvoll M, Hasenfuß G, Raaz U. Angiotensin Receptor-Neprilysin Inhibition (Sacubitril/Valsartan) Reduces Structural Arterial Stiffness in Middle-Aged Mice. J Am Heart Assoc. (2024)
Dannert A*, Klimmt J*, Cardoso Gonçalves C*, Crusius D, Paquet D. Reproducible and Scalable Differentiation of Highly Pure Cortical Neurons from Human Induced Pluripotent Stem Cells. STAR Protocols, 4(2), 102266. (2023)
Schellinger IN, Wagenhäuser M, Chodisetti G, Mattern K, Dannert A, Petzold A, Jakubizka-Smorag J, Emrich F, Haunschild J, Schuster A, Schwob E, Schulz K, Maegdefessel L, Spin JM, Stumvoll M, Hasenfuß G, Tsao PS, Raaz U. MicroRNA miR-29b regulates diabetic aortic remodeling and stiffening. Mol. Ther.Nucleic Acids 24, 188–199 (2021).
Schellinger IN*, Dannert A*, Mattern K, Raaz U & Tsao PS. Unresolved Issues in RNA Therapeutics in Vascular Diseases With a Focus on Aneurysm Disease. Front. Cardiovasc. Med. 8, 1–16 (2021).
Weisheit I, Kroeger JA, Malik R, Klimmt J, Crusius D, Dannert A, Dichgans M, Paquet D. Detection of Deleterious On-Target Effects after HDR-Mediated CRISPR Editing. Cell Rep. 31, 107689 (2020).
Klimmt J.*, Dannert A* & Paquet D. Neurodegeneration in a dish: advancing human stem-cell-based models of Alzheimer’s disease. Current Opinion in Neurobiology 61, 96–104 (2020).
* equal first authors
Scientific Talks & Outreach
Scientific Talks & Outreach
September 2024 - SyNergy PhD and Postdoc Representatives
I got elected by the community to be one of the PostDoc representatives of the SyNergy Cluster of Excellence in Munich, representing PostDocs from 55 research labs across the neuroscience community in Muich.
June 2024 - GSCN Annual Magazine
My talk at the annual conference at the Germany Stem Cell Network Conference in Ulm in September 2023 got covered in the 2024 GSCN Annual Magazine!
August 2023 - International Society for Molecular Neurodegeneration NextGen 2023
I had great fun to give a talk at the International Society for Molecular Neurodegeneration NextGen 2023 Virtual Conference. I'm more than excited to have won the Best Speaker Award.
May 2023 - Munich Brain Day
I was selected for a short Blitz Presentation at the Munich Brain Day, a great scientific event for the Munich Neuroscience community. I was quite nervous - pitching in front of 400 people - but had a great time nonetheless!
September 2022 - World Alzheimer's Day
I gave a small poster presentation at the World Alzheimer's Day event at the Center for Stroke and Dementia Research. The big difference to all the other poster presentations? It was in front of an lay audience! Explaining my research to significant others of people affected by dementia was a extremely rewarding experience and re-iterated the importance of our work for me!
August 2021, November 2021, July 2022 - Soapbox Science
Soapbox Science - bringing science to the streets and increasing the visibility of female scientists in the public! We organized three big public outreach events and I was impressed by the amazing female scientists that I got to interact with as member and head of the Speakers Team. Go Science!
October 2021 - FORSCHA Munich Science Days
At FORSCHA, the Munich Science Days, I spend a day at the museum to teach kids and their parents about neuroscience. The best part was teaching them how to use a microscope - everyone was really fascinated by the differences between a healthy and demented brain!
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